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    Home > Related Disease > Lupus Nephritis > Lupus Nephritis Basics >

    What Is Lupus Nephritis

    2013-11-07 14:34| Font Size A A A

    Lupus NephritisLupus Nephritis is known as a kind of CKD only by patients in most cases rather than specific cause and significance. Then what exactly it is? The follow-up content will give you a detailed introduction.

    Lupus Nephritis is commonly seen immune complex nephritis attributes to long-term SLE, which is the main secondary injury and cause of death of SLE. As a matter of fact, it is a kind of chronic and systemic autoimmune disease with various clinical features of multiple tissue and organs, which has a mass of varying autoantibodies especially antinuclear antibody in serum. Alternately evolutive acute attack and diseased remission is the characteristic of Lupus Nephritis while patients with organic damage such as involved kidney and nervous centralis suffer from poor prognosis. It is worth noting that the morbidity of Lupus Nephritis is 1/1000 in our contrary rather than 1/2000 which is reported in western contrary while female especially in their 20’s to 40’s are most susceptible.

    In fact, Lupus Nephritis is immune complex disease of human body against endogenous antigen, which is caused by numerous factors.

    1.Genetic & habitus:

    The morbidity of Lupus Nephritis for close relative is 5%~12% while identical twin is 3%. Blacj people and Asian people have significant high morbidity, which attributes to genetic factors. The gene of genetic predisposition of Lupus Nephritis is located in the sixth chromosome while women has higher morbidity attributes to the function of endocrine factors.

    2.Environment:

    While genetic factors and habitus is only susceptible tendency, environmental factors play a crucial role through virus infection, medicine factors and ultraviolet ray. Virus infection mainly attributes to poor immunity and long-term usage of immunosuppressive agent while medicine factors include penicillin, hydralazine, procainamide, methyldopa, isoniazid and quinindium,etc. 40% of patients have increased antigenicity after illumination, which speeds up the progression of Lupus Nephritis.

    What is Lupus Nephritis? The content above may offer you a general idea. If you want to know more about timely and effective treatments, please leave a message below or talk to our online service for free.


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