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    Home > Related Disease > Lupus Nephritis > Lupus Nephritis Basics >

    What is lupus nephritis?

    2019-01-20 14:55| Font Size A A A


    Today, we talked about what renal insufficiency is.

    Firstly, we need learn what lupus nephritis is?

    Lupus nephritis is renal inherent renal cells get injured because of toxins inside and outside of the body, manifestations include hematuria, proteinuria and etc.

    SLE is widely distributed around the world, with different incidence rates in different countries and regions.It is generally believed that there are significant differences in the incidence of different RACES. The incidence among black people and Asian people is high, while the incidence of white people is the lowest. The incidence of white people in foreign countries is about 50/100,000. Females are more than males, the ratio of men and women is 1:8 ~ 1:9,

    young adults are the main sufferers, 50% incidence in the 20 ~ 40 years old by clinical examination found renal involvement accounted for about 70%, general pathologic examination show 90% with the kidney involvement, if further inspection for immunofluorescence or network stations and electron microscope examination, almost all SLE patients have varying degrees of kidney disease.LN is also the most important secondary kidney disease.

    The main manifestations are fever, facial erythema, polymorphous skin rash, photoallergy, multiple oral ulcer, arthritis, multiple serositis, vasculitis, nephritis and symptoms of central nervous system etc.

    Then, what caused lupus nephritis?

    Due to the toxic and harmful substances from unhealthy life habit, they accumulate in human body and exceed the human body's ability to deal with them. As a result,the imbalance between the human body's inflammation and anti-inflammation balance get in trouble, tilting the human body towards the direction of inflammation.

    Abnormal activation of immune cells, self-injury of immune cells, exposure of nuclear or cytoplasmic components to immune attack, stimulation of the immune system as an antigen, the production of anti-nuclear antibodies and the combination of anti-smith antibodies, antigen-antibody, leading to excessive immune inflammation,

    High expression of Cytokine interleukin 6 and tumor necrosis factor and interleukin 4, TGF - beta, interleukin - 17, low expression of interleukin - 2 and interleukin 10, damage to the kidney inherent cells, red blood cells and plasma protein leak into the urine, form the bloody urine and urine protein, edema, high blood pressure, kidney function decline and other clinical manifestations, that is lupus nephritis.

    Alright, this is our today’s program about what lupus nephritis is.

    After knowing the diagnosis, you would ask why people would get lupus nephritis? Only we know the reason of this disease, we can expect how to treat it. Tomorrow, we will give you detailed explanation about the cause of this disease.

    Thanks for your watching and see you tomorrow.


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