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    Home > Related Disease > IgA Nephropathy > IgA Nephropathy Diagnosis >

    How to Diagnose IgA Nephropathy

    2013-11-05 14:27| Font Size A A A

    Diagnose, IgA NephropathyIgA Nephropathy is commonly seen autoimmune CKD with baneful influences, which is a real nightmare for patients. However, how to Diagnose it as soon as possible from a straw in the wind?

    As a matter of fact, IgA Nephropathy attributes to abnormal IgA globulin which forms immune complex with autoantibody, thus depositing in mesangial area and secreting inflammatory factors so as to cause renal damage. It is worth noting that without timely and effective treatment, patients with slight kidney-related symptoms will rapidly develop into severe systemic damage of multiple tissue and organs, which further leads to various clinical features with poor immunity.

    Then how to diagnose IgA Nephropathy efficiently and sufficiently? Specific factors are listed below.

    1.Immunologic test:

    50% of patients behave as increased content of serum IgA while 37%~75% of patients are detected with specific circulating immune complex which contains IgA.

    2.Proteinuria:

    Quantification and type of proteinuria are crucial for evaluation and prognosis of IgA Nephropathy. It mainly indicates slight and focal mesangial proliferative when proteinuria is less than 1g/24h while medium to advanced proteinuria reflects diffuse mesangial proliferation in most cases with crescent and glomerular sclerosis.

    3.Renal function:

    It often mirrors evolutional diseased condition when serum creatinine reaches 1.5mg/DL (132.6umol/L) while pathological damage develops to stage 3 CKD when GFR is less than 20ml/min.

    4.Hematuria:

    Red blood cells show as various shapes, which implies glomerular damage of IgA Nephropathy.

    In fact, pathology of renal biopsy as well as support of results of immunofluorescence and immunohistochemical techniques are necessary to diagnose IgA Nephropathy. The diagnosis characters are diffuse mesangial proliferation or focal segmental proliferative glomerulonephritis through light microscope, deposition of immune complex with a mass of IgA through immunofluorescence, etc.

    The content above mainly introduces how to diagnose IgA Nephropathy. If you still puzzle about your current condition, please leave a message below or talk to our online service for free.


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