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    Home > Related Disease > Diabetic Nephropathy > Diabetic Nephropathy Basics >

    Diabetic Nephropathy: What Stages Are You in?

    2013-10-26 13:45| Font Size A A A

    Stage, Diabetic NephropathyDiabetic Nephropathy is known as foremost complication of diabetes, which has already become the second-leading cause of End Stage Kidney Disease. However, those who suffer from it: do you exactly know what your current situation is? What Stages are you in?

    As a matter of fact, Diabetic nephropathy will become much more troublesome than other Kidney Diseases when it turns out to be advanced CKD, which attributes to its complicated metabolic disorders. Therefore, it is of great significance to receive timely and effective medication.

    Before that, it is essential for patients with Diabetic Nephropathy to make sure about their diseased condition of stages which are listed below, thus leading to appropriate and thorough treatment.

    Stage 1: High GFR period with hypertrophic kidneys

    This early change is in accordance with high blood sugar, which is able to be relieved with glycemic control. Few pathological injuries appear in this period.

    Stage 2: Conventional proteinuria period

    GFR is higher than normal, which mainly behaves as incrassated glomerular basement membrane and increased mesangial matrix. Urinary albumin excretion (UAE) rises after exercise, which gradually returns to normal with rest. It is worth noting that patients with Diabetic Nephropathy will stay steadily in this condition for a relatively long time with well glycemic control.

    Stage 3: Diabetic Nephropathy of early stage, known as continuous slight proteinuria period

    GFR starts to decline to normal, which indicates renal pathological changes of nodular nidus of glomerulus and hyaline lesions of arteriole. UAE continuously rises to 20~200μg/min with slight proteinuria, which can be eased with ACEI or ARB so as to slow down the progression of Diabetic Nephropathy.

    Stage 4: Clinical period of Diabetic Nephropathy

    K-W nodule appears as typical pathological change, which leads to heavy continuous proteinuria (UAE>200μg/min) or proteinuria of more than 500mg/d that Nephrotic Syndrome appears to 30% of patients with continuous GFR decline. The characteristic in this period is that proteinuria won’t decline with GFR.

    Stage 5: End Stage Renal Failure period

    Patients with Diabetic Nephropathy have less than 10ml/min GFR while protein in urine reduces with glomerular sclerosis. Various systemic symptoms and complications appear, which requires for dialysis.

    What stages of Diabetic Nephropathy are you in? If you have any questions about renal treatments, please leave a message below or talk to our online service for free.


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