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    Home > Related Disease > Diabetic Nephropathy > Diabetic Nephropathy Basics >

    What Are The Causes of Diabetic Nephropathy

    2013-10-24 14:35| Font Size A A A

    Causes of Diabetic NephropathyGenerally speaking, Diabetic Nephropathy attributes to long-term diabetes for 5~10 years, which is well known by most patients. However, what are the Causes of Diabetic Nephropathy? What are the influence factors?

    As the matter of fact, there is no explicit causes of Diabetic Nephropathy, which is widely believed as the consequence of multiple factors of certain genetic background and parts of risk factors.

    Genetic factors:

    The suffering percentage of male is higher than female while African and Mexican are more susceptible compared with the white race under the same living environment according to American research. Besides, certain families are easy to suffer from Diabetic Nephropathy, which points out the existence of genetic factors that slight proteinuria is diagnosed from 40%~50% patients of type 1 diabetes while 20%~30% patients with diabetes turn out to be Diabetic Nephropathy.

    Renal hemodynamic abnormalities:

    One of the significant causes of Diabetic Nephropathy that renal hemodynamic abnormalities can be detected in early period, which behaves as increased renal blood flow and GFR.

    Metabolic disorder attributes to hyperglycemia:

    Hemodynamic changes or metabolic disorders are main pathological injuries of renal damage caused by hyperglycemia while the former mainly includes partial insufficiency of carbohydrate metabolism of renal tissue and activation of polyol pathway, etc.


    It is most commonly seen cause of Diabetic Nephropathy that almost all the patients with Diabetic Nephropathy suffer from hypertension. Those with type 1 Diabetic Nephropathy suffer from hypertension and slight proteinuria simultaneously while type 2 suffer from hypertension in advance before Diabetic Nephropathy. In a word, the control of blood pressure is closely related to the progress of Diabetic Nephropathy.

    Metabolic disorder of vasoactive substances:

    There are various kinds of metabolic disorder of vasoactive substances, which includes RAS, ET, PG, growth factor and other metabolic disorders.

    The content above mainly introduces the causes of Diabetic Nephropathy. If you want to know more about CKD, please leave a message below or talk to our online service for free.

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